- On behalf of various U.S. and foreign biopharmaceutical manufacturers, located facilities with the appropriate capabilities for the preparation, process development, or commercial manufacture of: (1) a
recombinant protein from E. coli
for therapeutic use; (2) a recombinant monoclonal antibody; (3) a generic antibiotic; (4) a recombinant virus produced in human cell culture; (5) a recombinant protein from E. coli
used for nutritional purposes; (6) a recombinant protein used as a pharmaceutical
adjunct; and (7) a relatively large volume of
a low molecular weight specialty chemical. The assignments required varying degrees of involvement, but always encompassed providing a short list of possible facilities and an analysis of the strengths and weaknesses of the different facilities and staffs.
- Discussion with a major European chemical company with interests in biotechnology revealed a complementarity between their interests and those of a mid-size American company, which the European company had
approached unsuccessfully. Based on my acquaintance with senior management and an analysis of the benefits of working together, a meeting was arranged at which the two groups discussed their mutual
interests.
- A biotechnology company is developing a process for production of a specialty chemical by fermentation followed by chemical manipulation of the intermediate to yield the final product. Many process options
exist, and the client requested a cost analysis using preliminary data to serve as the basis for making some predictions of final product cost as well as to focus development efforts on the favorable routes.
- An evaluation was undertaken of the fermentation and downstream processing technology at a foreign manufacturer of pharmaceutical products. The aim was to identify competitive strengths and weaknesses and
to assist the company in increasing its manufacturing productivity for a number of processes.
As a result of our involvement, strain
improvement programs were successfully
implemented, and some significant
process improvements were made.
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