Penicillin:
A Paradigm for Biotechnology
Richard
I. Mateles, Editor
Reprints
The History of Penicillin Production,
the classic publication of the American Institute
of Chemical Engineers, originally published in
1970 and long out-of-print. It is updated by the
inclusion of two new chapters dealing with
scientific advances in penicillin biochemistry,
microbiology, and genetics made since 1970; and
the current commercial and industrial status of
penicillin and its derivatives.
This
book tells the remarkable story of penicillin's
progress from a laboratory curiosity to being the
first antibiotic available for regular use, and
still a very important product today. The
contributors to this book are the scientists and
engineers who played the major role in that
enterprise, which has served as a model for
fermentation development for the last fifty years.
Among
the penicillin program's "firsts,"
which continue to be important in biotechnology
today, were:
- mutation
and selection for microbial strain
improvement
- scale-up
of fermentors for aerobic processes
- countercurrent
liquid-liquid extraction
- industrial-scale
lyophilization of sterile pharmaceuticals
- Published:
December, 1998 xi + 114 pp.
ISBN 1-891545-01-9
To order a copy, mail this
form (or fax to 312-346-3345) to: Candida
Corporation, 77 West Washington Street, Suite 1616,
Chicago, IL 60602
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