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Penicillin: A Paradigm for Biotechnology

Richard I. Mateles, Editor

Reprints The History of Penicillin Production, the classic publication of the American Institute of Chemical Engineers, originally published in 1970 and long out-of-print. It is updated by the inclusion of two new chapters dealing with scientific advances in penicillin biochemistry, microbiology, and genetics made since 1970; and the current commercial and industrial status of penicillin and its derivatives.

This book tells the remarkable story of penicillin's progress from a laboratory curiosity to being the first antibiotic available for regular use, and still a very important product today. The contributors to this book are the scientists and engineers who played the major role in that enterprise, which has served as a model for fermentation development for the last fifty years.

Among the penicillin program's "firsts," which continue to be important in biotechnology today, were:

  • mutation and selection for microbial strain improvement
  • scale-up of fermentors for aerobic processes
  • countercurrent liquid-liquid extraction
  • industrial-scale lyophilization of sterile pharmaceuticals
  • Published: December, 1998 xi + 114 pp.
    ISBN 1-891545-01-9

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Updated 3/30/2010
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